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A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28.
Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
We report on a family in which nonsyndromal mild to moderate mental retardation segregates as an X-linked trait (MRX41). Two point linkage analysis demonstrated linkage between the disorder and marker DXS3 in Xq21.33 with a lod score of 2.56 at theta = 0.0 and marker DXS1108 in Xq28 with a lod score of 3.82 at theta = 0.0. Multipoint linkage analysis showed that the odds for a location of the gene in Xq28 vs Xq21.33 are 100:1. This is the fourth family with non-specific X-linked mental retardation with Xq28-qter as the most likely gene localization.
PMID: 8826463 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Renpenning syndrome maps to Xp11.
Stevenson RE, Arena JF, Ouzts E, Gibson A, Shokeir MH, Vnencak-Jones C, Lubs HA, May M, Schwartz CE.
Am J Hum Genet. 1998 May; 62(5):1092-101.
[Am J Hum Genet. 1998]
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A new X linked recessive syndrome of mental retardation and mild dysmorphism maps to Xq28.
Pai GS, Hane B, Joseph M, Nelson R, Hammond LS, Arena JF, Lubs HA, Stevenson RE, Schwartz CE.
J Med Genet. 1997 Jul; 34(7):529-34.
[J Med Genet. 1997]
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A gene for dominant nonspecific X-linked mental retardation is located in Xq28.
des Portes V, Billuart P, Carrié A, Bachner L, Bienvenu T, Vinet MC, Beldjord C, Ponsot G, Kahn A, Boué J, et al.
Am J Hum Genet. 1997 Apr; 60(4):903-9.
[Am J Hum Genet. 1997]