Genomics. 1996 Jan 15;31(2):240-2.

PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3.

Inazawa J, Ariyama T, Abe T, Druck T, Ohta M, Huebner K, Yanagisawa J, Reed JC, Sato T.

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Department of Hygiene, Kyoto Prefectural University of Medicine, Japan.

Abstract

PTPN13 is a protein tyrosine phosphatase that associates with the C-terminal negative regulatory domain in the Fas (APO-1/CD95) receptor. The PTPN13 protein contains six GLGF repeats that have been found in the rat postsynaptic density protein (PSD-95) and the Drosophila tumor suppressor protein, lethal-(1)-disc-large-1 (dlg-1). The localization of the PTPN13 gene to human chromosome 4q21.3 was determined by both FISH and PCR analysis of somatic cell hybrids. This 4q21.3 chromosomal region contains a gene for autosomal dominant polycystic kidney disease as well as the region frequently deleted in liver and ovarian cancers, suggesting that PTPN13 is a candidate for one of the putative tumor suppressor genes on the long arm of chromosome 4.

PMID:: 8824809; [PubMed - indexed for MEDLINE]

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The gene (PTPN13) encoding the protein tyrosine phosphatase PTP-BL/PTP-BAS is located in mouse chromosome region 5E/F and human chromosome region 4q21. [Cytogenet Cell Genet. 1996]
The gene (PTPN13) encoding the protein tyrosine phosphatase PTP-BL/PTP-BAS is located in mouse chromosome region 5E/F and human chromosome region 4q21.
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Cited by 9 PubMed Central articles

The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp). [J Biol Chem. 2012]
The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).
Huang W, Hu L, Bei L, Hjort E, Eklund EA. J Biol Chem. 2012 Mar 9; 287(11):8110-25. Epub 2012 Jan 18.
Review PTPN13/PTPL1: an important regulator of tumor aggressiveness. [Anticancer Agents Med Chem. 2011]
Review PTPN13/PTPL1: an important regulator of tumor aggressiveness.
Freiss G, Chalbos D. Anticancer Agents Med Chem. 2011 Jan; 11(1):78-88.
PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. [Cancer Res. 2010]
PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase.
Glondu-Lassis M, Dromard M, Lacroix-Triki M, Nirdé P, Puech C, Knani D, Chalbos D, Freiss G. Cancer Res. 2010 Jun 15; 70(12):5116-26. Epub 2010 May 25.

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PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long ar...
PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3.
Genomics. 1996 Jan 15 ;31(2):240-2.

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