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    Genomics. 1996 Jan 15;31(2):230-3.

    Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.

    Source

    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada.

    Abstract

    Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to be integrated into the genetic and physical map of chromosome 7.

    PMID:
    8824806
    [PubMed - indexed for MEDLINE]

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