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Genomics. 1996 Jan 15;31(2):230-3.

Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.

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  • 1Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada.


Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to be integrated into the genetic and physical map of chromosome 7.

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