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Thromb Haemost. 1996 Jun;75(6):945-9.

N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins.

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  • 1Institut National de la Santé et de la Recherche Médicale U.352, Chimie Biologique INSA-Lyon, Villeurbanne, France.


The effects of catechins were studied in both unstimulated platelets and platelets submitted to a mild oxidative stress induced by docosahexaenoic acid (DHA). Human unstimulated platelets were incubated in the presence of catechin or epicatechin (1, 10 or 100 microM) for 2 h at 37 degrees C. Treatment by 1 microM epicatechin was sufficient to induce a significant inhibition (-30%) of basal thromboxane B2 formation. This result is consistent with the observed inhibitory effects of flavonoids on platelet aggregation. DHA treatment of platelets decreased the amount of alpha-tocopherol and increased the malondialdehyde (MDA) formation. The presence of epicatechin or catechin prevented the oxidative stress induced by DHA. Indeed, the platelet alpha-tocopherol level was significantly increased when compared to that of platelets treated by DHA alone, to reach the control level, whereas MDA was depressed to a level even lower than the control one. Our results indicate that catechin and especially epicatechin protect platelets from a peroxidative stress.

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