Clin Exp Hypertens. 1996 Jan;18(1):1-19.

Hypertension, thermotolerance, and the "African gene": an hypothesis.

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Hypertension Section, VA Medical Center, St. Louis, Missouri 63106, USA.

Abstract

Hypertension is a polygenic disease of world-wide concern. So far, no polygenic disease has been solved at the genetic level. Ethnic differences in the prevalence of hypertension may suggest candidate genes worthy of study. A strong genetic predisposition to hypertension and target organ damage appears to correlate with African ancestry, referred to as "the African gene." Sub-Saharan Africans have endured the selective pressure of extreme heat for thousands of generations. Polymorphisms in the renin-angiotensin system, such as the recently described insertion/deletion polymorphism in the angiotensin I converting enzyme (ACE) gene, may predispose to hypertension and related disorders because of an advantage they confer in thermoregulation.

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