The implications for childhood leukemia of infecti...[Trends Microbiol. 1996]

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1: Trends Microbiol. 1996 Feb;4(2):60-3. Links

The implications for childhood leukemia of infection with adenovirus.

Dorak MT.

Department of Haematology, University of Wales College of Medicine, Cardiff, UK.

Adenoviruses have mechanisms that allow persistence in lymphoid cells and immunoevasion. They downregulate major histocompatibility complex (MHC) class I antigen expression and may trigger an autoimmune reaction against MHC class II antigens through mimicry. Adenoviral persistence could be facilitated by human leukocyte antigens A2 and DR53, thereby allowing a preleukemic clone to escape immune surveillance and progress to leukemia.

PMID: 8820568 [PubMed - indexed for MEDLINE]

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