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1: Pharmacotherapy. 1996 Mar-Apr;16(2):314-6.Links

Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction.

Spivey JM, Cummings DM, Pierson NR.

Department of Family Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA.

Metal cations such as aluminum, magnesium, ferrous sulfate, and zinc are thought to form chelation complexes with fluoroquinolone antibiotics and prevent the drugs from being absorbed. Sucralfate, which has a high aluminum content, reduces the bioavailability of ciprofloxacin to approximately 4%. The concomitant administration of ciprofloxacin and sucralfate resulted in treatment failure for a patient with prostatitis and a subsequent 5-day hospitalization. Fluoroquinolone antibiotics should be administered at least 2 hours before agents containing metal cations to allow for their absorption. In addition, sucralfate should not be administered less than 6 hours before fluoroquinolone antibiotic administration.

PMID: 8820479 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Ciprofloxacin (Cipro® , Cipro® XR, Proquin® XR)

    Ciprofloxacin is used to treat or prevent certain infections caused by bacteria. Ciprofloxacin is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in...

  • Sucralfate (Carafate® )

    Sucralfate is used to treat ulcers. It adheres to damaged ulcer tissue and protects against acid and enzymes so healing can occur.

  • Source: AHFS Consumer Medication Information