Pharmacotherapy. 1996 Mar-Apr;16(2):314-6.

Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction.

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Department of Family Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA.

Abstract

Metal cations such as aluminum, magnesium, ferrous sulfate, and zinc are thought to form chelation complexes with fluoroquinolone antibiotics and prevent the drugs from being absorbed. Sucralfate, which has a high aluminum content, reduces the bioavailability of ciprofloxacin to approximately 4%. The concomitant administration of ciprofloxacin and sucralfate resulted in treatment failure for a patient with prostatitis and a subsequent 5-day hospitalization. Fluoroquinolone antibiotics should be administered at least 2 hours before agents containing metal cations to allow for their absorption. In addition, sucralfate should not be administered less than 6 hours before fluoroquinolone antibiotic administration.

PMID:: 8820479; [PubMed - indexed for MEDLINE]

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