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Immunol Today. 1996 Mar;17(3):131-7.

A new foreign policy: MHC class I molecules monitor the outside world.

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  • 1Division of Lymphocyte Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA.


Although most cells exclusively use their major histocompatibility complex (MHC) class I molecules to present peptides from endogenous proteins, phagocytes also use them to present exogenous antigens. Here, Kenneth Rock describes how this novel antigen-presenting pathway may play an important role in immune surveillance for intracellular bacteria or parasites, as well as for viral infections and tumors affecting somatic tissues.

[PubMed - indexed for MEDLINE]
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