Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Res. 1996 Mar 18;712(2):345-8.

A newly-synthesized GPI-anchored protein, TAG-1/axonin-1, is inserted into axonal membranes along the entire length of the axon and not exclusively at the growth cone.

Author information

  • 1Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.

Abstract

Evidence exists that some newly-synthesized membrane components are inserted into the membrane of the growing axon at the growth cone. We now examine the site of insertion of a glycosylphosphatidylinositol-anchored protein, TAG-1/axonin-1. The protein was cleaved from the plasma membrane by phosphatidylinositol-specific phospholipase C. Newly-synthesized TAG-1/axonin-1 was subsequently detected along the entire length of the axonal membrane, with no evidence for preferential insertion at the distal end. These results raise the possibility that different subsets of proteins are inserted at different locations in axonal membranes.

PMID:
8814912
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk