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Genomics. 1996 Aug 1;35(3):617-9.

Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3.

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  • 1Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA.

Abstract

We describe the isolation and chromosomal mapping of a mouse homolog of the Batten disease gene, CLN3. Like its human counterpart, the mouse cDNA contains an open reading frame of 1314 bp encoding a predicted protein product of 438 amino acids. The mouse and human coding regions are 82 and 85% identical at the nucleic acid and amino acid levels, respectively. The mouse gene maps to distal Chromosome 7, in a region containing genes whose homologs are on human chromosome 16p12, where CLN3 maps. Isolation of a mouse CLN3 homolog will facilitate the creation of a mouse model of Batten disease.

PMID:
8812504
[PubMed - indexed for MEDLINE]
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