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1: Genomics. 1996 Aug 15;36(1):182-4.Click here to read Links

The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34.

Brunialti AL, Harding CO, Wolff JA, Guénet JL.

Institut Pasteur à Paris, 25 rue du Docteur Roux, Paris Cedex 15, 75724, France.

The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.

PMID: 8812433 [PubMed - indexed for MEDLINE]