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Immunol Today. 1996 Feb;17(2):86-91.

Inhibitory MHC class I receptors on NK cells and T cells.

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  • 1DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.


Natural killer (NK) and T cells express receptors for polymorphic major histocompatibility complex (MHC) class I molecules, and activation of these receptors results in inhibition of their effector cell function. Genes encoding the murine and human NK-cell receptors have been cloned, and studies of their structure, function and expression are progressing rapidly, as reviewed here by Lewis Lanier and Joseph Phillips.

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