Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock

F Genovese; G Mancuso; M Cuzzola; V Cusumano; F Nicoletti; K Bendtzen; G Teti

doi:10.1128/AAC.40.7.1733

Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock

Antimicrob Agents Chemother. 1996 Jul;40(7):1733-5. doi: 10.1128/AAC.40.7.1733.

Authors

F Genovese¹, G Mancuso, M Cuzzola, V Cusumano, F Nicoletti, K Bendtzen, G Teti

Affiliation

¹ Institute of Microbiology, University of Messina, Italy.

Abstract

Unlike the antibiotics erythromycin and penicillin G, sodium fusidate (fusidin) pretreatment (80 mg/kg of body weight) increased the survival rate of neonatal BALB/c mice challenged with Salmonella enteritidis lipopolysaccharide. Fusidin also significantly reduced the plasma tumor necrosis factor alpha levels. Hence, fusidin may prove useful in the management of bacterial sepsis in humans.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology*
Disease Models, Animal
Female
Fusidic Acid / pharmacology*
Lipopolysaccharides
Male
Mice
Mice, Inbred BALB C
Shock, Septic / blood
Shock, Septic / drug therapy*
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Tumor Necrosis Factor-alpha / metabolism

Substances

Anti-Bacterial Agents
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Fusidic Acid