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Structure. 1996 Jul 15;4(7):763-7.

Poliovirus: new insights from an old paradigm.

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  • 1Committee for Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138, USA.


A combination of structural and genetic studies of poliovirus suggests that the final stages of viral assembly lock the virus in a metastable structure primed to undergo the receptor-catalyzed conformational changes required for cell entry. Future studies promise to provide detailed insights into the conformational dynamics of the virion during its life cycle.

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