Closing the gap on DNA ligase

Structure. 1996 Jun 15;4(6):653-6. doi: 10.1016/s0969-2126(96)00070-6.

Abstract

The crystal structure of T7 DNA ligase complexed with ATP illuminates the mechanism of covalent catalysis by a superfamily of nucleotidyl transferases that includes the ATP-dependent polynucleotide ligases and the GTP-dependent mRNA capping enzymes.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Adenosine Triphosphate / metabolism
  • Amino Acid Sequence
  • Binding Sites
  • Conserved Sequence / genetics
  • Crystallography, X-Ray
  • DNA Ligase ATP
  • DNA Ligases / chemistry*
  • Models, Molecular
  • Molecular Sequence Data
  • Nucleotidyltransferases / chemistry
  • Protein Conformation

Substances

  • Adenosine Triphosphate
  • Nucleotidyltransferases
  • DNA Ligases
  • DNA Ligase ATP