Abstract
The crystal structure of T7 DNA ligase complexed with ATP illuminates the mechanism of covalent catalysis by a superfamily of nucleotidyl transferases that includes the ATP-dependent polynucleotide ligases and the GTP-dependent mRNA capping enzymes.
MeSH terms
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Adenosine Triphosphate / chemistry
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Adenosine Triphosphate / metabolism
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Amino Acid Sequence
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Binding Sites
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Conserved Sequence / genetics
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Crystallography, X-Ray
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DNA Ligase ATP
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DNA Ligases / chemistry*
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Models, Molecular
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Molecular Sequence Data
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Nucleotidyltransferases / chemistry
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Protein Conformation
Substances
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Adenosine Triphosphate
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Nucleotidyltransferases
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DNA Ligases
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DNA Ligase ATP