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Curr Biol. 1996 May 1;6(5):533-6.

A difficult phase for introns-early. Molecular evolution.

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  • 1Department of Genetics, Downing Street, Cambridge, CB2 3EH, UK.


Close analysis of intron phase - the position of introns within codons - is claimed to provide novel evidence supporting the view that introns predate the divergence of bacteria and eukaryotes and, via 'exon shuffling', played a crucial role in protein evolution. But just how compelling is this evidence?

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