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Mol Med Today. 1996 May;2(5):198-204.

Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease.

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  • Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. barrett-rollins@macmailgw.dfci.harvard.edu


The appearance of specific types of leukocytes in inflammatory infiltrates may be governed by cell-specific chemoattractants called chemokines. In particular, monocyte chemoattractant protein 1 (MCP-1) has been implicated in diseases characterized by monocyte-rich infiltrates, including atherosclerosis, rheumatoid arthritis and multiple sclerosis. While we are beginning to understand the structural determinants that govern the activities of MCP-1 in vitro, we know much less about its physiological functions in vivo and its pathogenetic role in disease. However, recent data from genetically modified mice have begun to place MCP-1 in a central position in monocyte trafficking and activation.

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