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Am J Gastroenterol. 1996 Sep;91(9):1814-6.

Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis.

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  • 1Division of Gastroenterology, University of Texas Medical School, Houston, USA.

Abstract

BACKGROUND:

Radiation proctitis is a common complication of abdominal and pelvic radiotherapy; unfortunately, there is no established effective therapy for radiation proctitis. Short-chain fatty acids (SCFA) have been effectively used to treat a variety of colitides. We sought to determine whether SCFA enemas have a role in the treatment of radiation proctitis.

METHODS:

Seven patients completed an open-labeled, pilot study to evaluate the effect of SCFA on clinical, endoscopic, and pathological parameters of radiation proctitis.

RESULTS:

Four weeks of treatment with SCFA enemas resulted in clinical improvement in all patients. There were modest, but not significant, changes in endoscopic and pathological parameters.

CONCLUSION:

SCFA are a promising therapeutic option in radiation proctitis.

PMID:
8792704
[PubMed - indexed for MEDLINE]
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