Am J Obstet Gynecol. 1977 Jul 1;128(5):486-8.

Antenatal exposure to the phenothiazines in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score.

Slone D, Siskind V, Heinonen OP, Monson RR, Kaufman DW, Shapiro S.

Abstract

In a prospective cohort study of 50,282 gravidas and their offspring, over-all rates of congenital malformations were similar in 1,309 children of women exposed to phenothiazine drugs during the first four lunar months of pregnancy and in 48,973 children of women who were not exposed. There was a suspicion of association between phenothiazine exposure and cardiovascular malformations. In a cohort reduced to 41,337 mother-child pairs for technical reasons, perinatal mortality rates and mean birth weight were similar according to phenothiazine exposure or nonexposure, as were intelligence quotient scores measured at four years of age in 28,358 of the children. Control of potential confounding factors with a variety of multivariate techniques did not materially alter the findings.

PMID:: 879206; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Phenothiazines

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Pregnancy and Medicines - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. [Am J Obstet Gynecol. 1977]
Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score.
Shapiro S, Heinonen OP, Siskind V, Kaufman DW, Monson RR, Slone D. Am J Obstet Gynecol. 1977 Jul 1; 128(5):480-5.
Antenatal exposure to meprobamate and chlordiazepoxide in relation to malformations, mental development, and childhood mortality. [N Engl J Med. 1975]
Antenatal exposure to meprobamate and chlordiazepoxide in relation to malformations, mental development, and childhood mortality.
Hartz SC, Heinonen OP, Shapiro S, Siskind V, Slone D. N Engl J Med. 1975 Apr 3; 292(14):726-8.
The health consequences of teenage fertility. [Fam Plann Perspect. 1985]
The health consequences of teenage fertility.
Makinson C. Fam Plann Perspect. 1985 May-Jun; 17(3):132-9.
Review The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis. [Br J Obstet Gynaecol. 1998]
Review The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis.
Brocklehurst P, French R. Br J Obstet Gynaecol. 1998 Aug; 105(8):836-48.
Review Spermicidal contraceptives and poor reproductive outcomes: the epidemiologic evidence against an association. [Am J Obstet Gynecol. 1985]
Review Spermicidal contraceptives and poor reproductive outcomes: the epidemiologic evidence against an association.
Bracken MB. Am J Obstet Gynecol. 1985 Mar 1; 151(5):552-6.

See reviews... See all...

Cited by 6 PubMed Central articles

Antinauseants in pregnancy: teratogens or not? [Can Fam Physician. 1984]
Antinauseants in pregnancy: teratogens or not?
Biringer A. Can Fam Physician. 1984 Oct; 30:2123-5.
Pregnancy and schizophrenia. [Can Fam Physician. 1984]
Pregnancy and schizophrenia.
Stewart D. Can Fam Physician. 1984 Jul; 30:1537-42.
The use of psychotropic drugs in pregnancy and lactation. [Can Fam Physician. 1986]
The use of psychotropic drugs in pregnancy and lactation.
Misri S. Can Fam Physician. 1986 Oct; 32:2155-8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Antenatal exposure to the phenothiazines in relation to congenital malformations...
Antenatal exposure to the phenothiazines in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score.
Am J Obstet Gynecol. 1977 Jul 1 ;128(5):486-8.

PubMed
The sepsis syndrome. Definition and general approach to management.
The sepsis syndrome. Definition and general approach to management.
Clin Chest Med. 1996 Jun ;17(2):175-81.

PubMed
Preliminary evaluation of fluid-attenuated inversion-recovery MR in the diagnosi...
Preliminary evaluation of fluid-attenuated inversion-recovery MR in the diagnosis of intracranial tumors.
AJNR Am J Neuroradiol. 1996 Jun-Jul ;17(6):1081-6.

PubMed
Probable genetic linkage between autosomal dominant retinitis pigmentosa (RP) an...
Probable genetic linkage between autosomal dominant retinitis pigmentosa (RP) and amylase (AMY2): evidence of an RP locus on chromosome 1.
Am J Hum Genet. 1977 Jul ;29(4):397-404.

PubMed
Role of macrophage-derived cytokines in the induction and regulation of cell-med...
Role of macrophage-derived cytokines in the induction and regulation of cell-mediated immunity to Toxoplasma gondii.
Curr Top Microbiol Immunol. 1996 ;219:127-39.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: