Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 1996 Aug;6(4):439-44.

Early mouse development: lessons from gene targeting.

Author information

  • 1Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, 16 Divinity Avenue, Cambridge, Massachusetts, 02138 USA. bstjacques@hubio2.harvard.edu

Abstract

A number of mouse mutants generated recently by gene targeting are of particular interest for the study of development. For some genes, such as Lim 1 or Otx-2, recent knockouts reveal an essential role in early patterning. In other cases, such as the activins and goosecoid, the mutant phenotypes force a re-evaluation of models that are based on studies in other vertebrates. Of particular interest also are the new compound mutants for genes where some measure of functional redundancy is expected, notably the Hox genes. Finally, recent technical advances allow the creation of conditional knockouts as well as large chromosomal alterations.

PMID:
8791525
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk