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Curr Opin Cell Biol. 1996 Aug;8(4):490-5.

Ligand-gated calcium channels inside and out.

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  • 1Department of Physiology, Universityof Connecticut, 263 Farmington Avenue, Farmington, CT 06030-3505, USA.


Calcium release from intracellular stores occurs through two types of channels associated with intracellular membranes, namely, the ryanodine receptor and the inositol 1,4,5-trisphosphate receptor. Recently, it has been shown that these channels are regulated by allosteric mechanisms and associated proteins. Release of intracellular calcium induces the opening of calcium-permeable channels on the plasma membrane. Current work has focused on the molecular and functional characterization of these channels which have been identified as store-operated channels or calcium release activated channels.

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