J Neurol Sci. 1996 Jun;138(1-2):157-60.

Panencephalitic Creutzfeldt-Jakob disease. Unusual presentation of magnetic resonance imaging and proton magnetic resonance spectroscopy.

Shyu WC, Lee CC, Hsu YD, Lin JC, Lee JT, Lee WH, Tsao WL.

Source

Department of Neurology, Tri-Service General Hospital and National Defence Medical Center, Taipei, Taiwan, R.O.C.

Abstract

We present serial magnetic resonance imaging (MRI) scans on a biopsy-verified case of Creutzfeldt-Jakob disease (CJD). The initial MRI scan demonstrated increased T2 signal-intensity within the basal ganglia and thalami. Subsequent MRI scans demonstrated a thin cortex, increased T2 signals diffusely within the white matter including U-fibers, and hypointense T2 signals within the basal ganglia, and thalami. Proton magnetic resonance spectroscopy (1H-MRS) study showed an absence of creatine, choline and N-acetylaspartate signals. By these characteristic findings, serial MRI and MRS studies may be helpful in differentiating CJD from other dementing illnesses.

Comment in

J Neurol Sci. 1997 Aug;149(2):197; author reply 199-200.

PMID:: 8791254; [PubMed - indexed for MEDLINE]

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