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Neuropharmacology. 1995 Dec;34(12):1647-51.

Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat.

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  • 1Department of Pharmacology and Therapeutics, Clinics Hospital, Montevideo, Uruguay.

Abstract

The effects of the 5-HT1B receptor agonist CP-94,253 were compared with those of the mixed beta-adrenoceptor and 5-HT1A/B receptor antagonist (+/-)pindolol in rats implanted for chronic sleep recordings. CP-94,253 (5.0-10.0 mg/kg) significantly increased waking and reduced slow wave sleep (SWS) and REM sleep (REMS). At 2.0-4.0 mg/kg (+/-)pindolol reduced REMS. Pretreatment with (+/-)pindolol (2.0-4.0 mg/kg) reversed the effect of CP-94,253 on waking and SWS, while REMS remained suppressed. It is suggested that the 5-HT1B receptor together with other 5-HT receptor subtypes may have a direct regulatory action on sleep and waking in the rat.

PMID:
8788962
[PubMed - indexed for MEDLINE]
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