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Biochem Biophys Res Commun. 1996 Aug 23;225(3):932-8.

Cloning and expression of cDNA for O-acetylation of GD3 ganglioside.

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  • 1Department of Tumor Immunology, Tokyo Metropolitan Institute of Medical Science, Japan.

Abstract

O-acetylated sialic acids of glycoproteins and gangliosides show cell type-specific and developmentally regulated expression in various systems and sometimes reappear as oncofetal antigens. O-acetylation of sialic acids may influence cell-cell interactions mediated by the sialic acid-binding lectins. Here we describe the molecular cloning and sequencing of a gene that produces O-acetyl disialoganglioside (O-acetyl GD3). Expression analysis showed that this gene product participates the O-acetylation of GD3 ganglioside sialic acid. The deduced amino acid sequence of the product was found to be similar to the milk fat globule membrane glycoprotein.

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