Format

Send to:

Choose Destination
See comment in PubMed Commons below
JAMA. 1996 Aug 28;276(8):615-9.

Results of radical prostatectomy in men with clinically localized prostate cancer.

Author information

  • 1Section of Urology, Department of Surgery, University of Chicago (III) Pritzker School of Medicine, IL 60637, USA.

Abstract

OBJECTIVE:

To assess the results of radical prostatectomy in men with early prostate cancer.

DESIGN:

Retrospective, nonrandomized, multi-institutional pooled analysis.

SETTING:

Eight university medical centers in the United States and Europe.

PATIENTS:

A total of 2758 men with stage Tl and T2 prostatic cancer.

MAIN OUTCOME MEASURES:

Disease-specific and metastasis-free survival rates.

RESULTS:

Tumor grade was the most important preoperative factor in determining outcome. Disease-specific survival 10 years following surgery and associated 95% confidence intervals were 94% (range, 87%-98%), 80% (range, 74%-85%), and 77% (range, 65%-86%) for those men with grade 1, 2, and 3 tumors, respectively. Metastasis-free survival at 10 years was 87% (range, 78%-92%), 68% (range, 62%-73%), and 52% (range, 38%-64%) for patients with grade 1, 2, and 3 cancers, respectively.

CONCLUSIONS:

Radical prostatectomy leads to high 10-year disease-specific survival rates in men with all tumor grades. However, caution is needed in comparing these results with similar studies of alternative treatment strategies, such as watchful waiting, due to the inherent potential biases in uncontrolled trials. Nevertheless, these results offer the best currently available estimates of 10-year outcome of radical prostatectomy in men with clinically localized prostate cancer and may be useful in counseling patients with early malignancy.

PMID:
8773633
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk