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Trends Biochem Sci. 1996 Aug;21(8):312-5.

More on target with protein phosphorylation: conferring specificity by location.

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  • 1Vollum Institute L474, Oregon Health Sciences University, Portland 97020-3098, USA.


One important regulatory mechanism in the control of phosphorylation events is the subcellular location of phosphatases of kinases. Several serine/threonine phosphatases and kinases have now been shown to be associated with targeting subunits; these contribute to the organization and specificity of signal transduction pathways by favoring the accessibility of their enzymes to certain substrates.

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