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Trends Biochem Sci. 1996 Aug;21(8):296-301.

The SR protein family: pleiotropic functions in pre-mRNA splicing.

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  • 1Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.


A family of proteins with arginine-serine-rich domains has recently come into the limelight of studies on the mechanisms of constitutive and regulated pre-mRNA splicing. Implicated in an ever increasing variety of functions, these proteins act as driving forces during spliceosome assembly and also play decisive roles in alternative splice-site selection, suggesting that they are crucial players in the regulation of splicing during cell differentiation and development.

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