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Br J Dermatol. 1996 Jun;134(6):1052-6.

Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases.

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  • 1Clinica Dermatologica I dell'Universit√† di Torino, Italy.


CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using immunohistochemical techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T-cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers. CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26 molecule may function as a keratinocyte activation antigen.

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