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1: Lancet. 1979 May 5;1(8123):954-6.Links

Therapeutic efficacy of apomorphine combined with an extracerebral inhibitor of dopamine receptors in Parkinson's disease.

Corsini GU, Del Zompo M, Gessa GL, Mangoni A.

Apomorphine in combination with a peripheral dopamine receptor blocker (domeperidone) was administered to four parkinsonian patients in a double-blind placebo-controlled study. The therapeutic efficacy of apomorphine was not reduced by domperidone, while nausea, drowsiness, sedation, and arterial hypotension were prevented. Combination of domperidone with dopamine agonists may result in more effective treatment of Parkinson's disease.

PMID: 87620 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Apomorphine (Apokyn® )

    Apomorphine is used to treat ''off'' episodes (times of difficulty moving, walking, and speaking that may happen as medication wears off or at random) in patients with Parkinson's disease (PD; a disorder of the nervous s...

  • Source: AHFS Consumer Medication Information