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Carcinogenesis. 1996 Aug;17(8):1633-9.

Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures.

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  • 1Department of Experimental Haematology, MRC Radiation and Genome Stability Unit, Harwell, Oxon.


There is accumulating evidence that cells exposed to low and often environmentally relevant doses of ionizing radiation survive the initial insult, but transmit genomic instability to their progeny. The underlying mechanism of radiation-induced genomic instability is unknown. We present bio-chemical evidence consistent with the hypothesis that enhanced and persistent oxy-radical activity may be responsible.

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