Lancet. 1978 Jan 21;1(8056):123-4.

Uptake of iron by duodenal biopsy specimens from patients with iron-deficiency anaemia and primary haemochromatosis.

Abstract

Iron uptake by human duodenal mucosa in vitro was considerably higher in iron-deficient patients than in controls. In biopsy specimens taken after treatment with iron, uptake fell to normal levels, although total iron in the mucosa remained low. In iron-overloaded patients with primary haemochromatosis, there was inappropriately high uptake of iron by the biopsy specimens. Kinetic analysis suggested that this was the result of affinity for iron being increased in a carrier in the enterocyte.

PMID:: 87554; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Iron

LinkOut - more resources

Full Text Sources

Elsevier Science

Medical

Molecular Biology Databases

IRON - HSDB

Supplemental Content

Save items

Related citations in PubMed

In vitro studies of duodenal iron uptake in patients with primary and secondary iron storage disease. [Q J Med. 1980]
In vitro studies of duodenal iron uptake in patients with primary and secondary iron storage disease.
Cox TM, Peters TJ. Q J Med. 1980; 49(195):249-57.
Cellular mechanisms in the regulation of iron absorption by the human intestine: studies in patients with iron deficiency before and after treatment. [Br J Haematol. 1980]
Cellular mechanisms in the regulation of iron absorption by the human intestine: studies in patients with iron deficiency before and after treatment.
Cox TM, Peters TJ. Br J Haematol. 1980 Jan; 44(1):75-86.
A duodenal mucosal abnormality in the reduction of Fe(III) in patients with genetic haemochromatosis. [Gut. 1996]
A duodenal mucosal abnormality in the reduction of Fe(III) in patients with genetic haemochromatosis.
Raja KB, Pountney D, Bomford A, Przemioslo R, Sherman D, Simpson RJ, Williams R, Peters TJ. Gut. 1996 May; 38(5):765-9.
Review [Iron absorption]. [Schweiz Med Wochenschr. 1971]
Review [Iron absorption].
Ganzoni AM. Schweiz Med Wochenschr. 1971 Nov 6; 101(44):1569-75.
Review Iron homeostasis: new tales from the crypt. [Blood. 2000]
Review Iron homeostasis: new tales from the crypt.
Roy CN, Enns CA. Blood. 2000 Dec 15; 96(13):4020-7.

See reviews... See all...

Cited by 12 PubMed Central articles

The hemochromatosis protein HFE inhibits iron export from macrophages. [Proc Natl Acad Sci U S A. 2002]
The hemochromatosis protein HFE inhibits iron export from macrophages.
Drakesmith H, Sweetland E, Schimanski L, Edwards J, Cowley D, Ashraf M, Bastin J, Townsend AR. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15602-7. Epub 2002 Nov 12.
Review Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. [Proc Natl Acad Sci U S A. 2001]
Review Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease.
Fleming RE, Sly WS. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8160-2.
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. [Proc Natl Acad Sci U S A. 1999]
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum.
Waheed A, Parkkila S, Saarnio J, Fleming RE, Zhou XY, Tomatsu S, Britton RS, Bacon BR, Sly WS. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1579-84.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Uptake of iron by duodenal biopsy specimens from patients with iron-deficiency a...
Uptake of iron by duodenal biopsy specimens from patients with iron-deficiency anaemia and primary haemochromatosis.
Lancet. 1978 Jan 21 ;1(8056):123-4.

PubMed
PEST sequences and regulation by proteolysis.
PEST sequences and regulation by proteolysis.
Trends Biochem Sci. 1996 Jul ;21(7):267-71.

PubMed
Pleckstrin's repeat performance: a novel domain in G-protein signaling?
Pleckstrin's repeat performance: a novel domain in G-protein signaling?
Trends Biochem Sci. 1996 Jul ;21(7):245-6.

PubMed
The sensitivity of Cockayne's syndrome cells to DNA-damaging agents is not due t...
The sensitivity of Cockayne's syndrome cells to DNA-damaging agents is not due to defective transcription-coupled repair of active genes.
Mol Cell Biol. 1996 Aug ;16(8):4436-44.

PubMed
Multiple protein factors interact with the cis-regulatory elements of the proxim...
Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine beta-hydroxylase gene.
J Neurosci. 1996 Jul 1 ;16(13):4102-12.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: