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    J Med Chem. 1977 Jul;20(7):952-6.

    Synthesis and central nervous system evaluation of some 5-alkoxy-3H-1,4-benzodiazepin-2(1H)-ones.

    Gogerty JH, Griot RG, Habeck D, Iorio LC, Houlihan WJ.

    A series of 1-R-5-alkoxy-3H-1,4-benzodiazepin-2(1H)-ones was prepared and evaluated for central nervous system depressant activity. Several of these compounds, in particular, 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2(1H)-one (2), gave a profile and activity level similar to diazepam when measured in mice.

    PMID: 874970 [PubMed - indexed for MEDLINE]

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