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    J Pharm Sci. 1977 May;66(5):676-80.

    Effect of temperature and relative humidity on nitrazepam stability in solid state.

    Genton D, Kesselring UW.

    Abstract

    The decomposition of a 1% dilution of nitrazepam in microcrystalline cellulose was established by quantitative determination of the two main breakdown products, 2-amino-5-nitrobenzophenone and 3-amino-6-nitro-4-phenyl-2(1H)-quinolone, using in situ diffuse reflectance measurements on thin-layer chromatograms. The decomposition and formation rate constant of nitrazepam and of the breakdown products, respectively, were determined at four temperatures and six relative humidities. By means of a three-parameter regression equation, it was possible to correlate quantitatively the decomposition constant of nitrazepam to both temperature and relative humidity.

    PMID:
    874750
    [PubMed - indexed for MEDLINE]

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