Trends Biochem Sci. 1996 Jun;21(6):208-14.

Does this have a familiar RING?

Saurin AJ, Borden KL, Boddy MN, Freemont PS.

Source

Protein Structure Laboratory, Imperial Cancer Research Fund, London, UK.

Abstract

The RING finger is a zinc-binding domain that is found in proteins from plants to humans, but whose function remains largely enigmatic. The domain itself is distinct from other zinc-finger motifs in terms of sequence homology, zinc-ligation scheme and three-dimensional structure. It appears that the RING is involved in mediating protein-protein interactions and in some cases multi-protein complexes, which might depend on the presence of other proteins and/or domains.

PMID:: 8744354; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

Treble clef finger--a functionally diverse zinc-binding structural motif. [Nucleic Acids Res. 2001]
Treble clef finger--a functionally diverse zinc-binding structural motif.
Grishin NV. Nucleic Acids Res. 2001 Apr 15; 29(8):1703-14.
CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions. [J Biol Chem. 2003]
CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions.
Simpson RJ, Cram ED, Czolij R, Matthews JM, Crossley M, Mackay JP. J Biol Chem. 2003 Jul 25; 278(30):28011-8. Epub 2003 May 7.
Mutational analysis and NMR spectroscopy of quail cysteine and glycine-rich protein CRP2 reveal an intrinsic segmental flexibility of LIM domains. [J Mol Biol. 1999]
Mutational analysis and NMR spectroscopy of quail cysteine and glycine-rich protein CRP2 reveal an intrinsic segmental flexibility of LIM domains.
Kloiber K, Weiskirchen R, Kräutler B, Bister K, Konrat R. J Mol Biol. 1999 Oct 1; 292(4):893-908.
Review Zinc fingers--folds for many occasions. [IUBMB Life. 2002]
Review Zinc fingers--folds for many occasions.
Matthews JM, Sunde M. IUBMB Life. 2002 Dec; 54(6):351-5.
Review Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules. [J Biol Chem. 1990]
Review Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules.
Berg JM. J Biol Chem. 1990 Apr 25; 265(12):6513-6.

See reviews... See all...

Cited by over 100 PubMed Central articles

Review KAP1 protein: an enigmatic master regulator of the genome. [J Biol Chem. 2011]
Review KAP1 protein: an enigmatic master regulator of the genome.
Iyengar S, Farnham PJ. J Biol Chem. 2011 Jul 29; 286(30):26267-76. Epub 2011 Jun 7.
A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells. [Cell Death Differ. 2011]
A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells.
Pao PC, Huang NK, Liu YW, Yeh SH, Lin ST, Hsieh CP, Huang AM, Huang HS, Tseng JT, Chang WC, et al. Cell Death Differ. 2011 Nov; 18(11):1791-804. Epub 2011 May 13.
SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability. [PLoS Genet. 2011]
SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.
Heideker J, Prudden J, Perry JJ, Tainer JA, Boddy MN. PLoS Genet. 2011 Mar; 7(3):e1001320. Epub 2011 Mar 3.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Protein Clusters
Clusters of related proteins from the Protein Clusters database that cite the current articles. Sources of references in Protein Clusters include the associated Gene and Conserved Domain records as well as NCBI added citations.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Does this have a familiar RING?
Does this have a familiar RING?
Trends Biochem Sci. 1996 Jun ;21(6):208-14.

PubMed
Neuronal nicotinic acetylcholine receptors.
Neuronal nicotinic acetylcholine receptors.
Ion Channels. 1996 ;4:377-450.

PubMed
Accuracy of 133-xenon regional cerebral blood flow and quantitative electroencep...
Accuracy of 133-xenon regional cerebral blood flow and quantitative electroencephalography in systemic lupus erythematosus.
Lupus. 1996 Apr ;5(2):93-102.

PubMed
Lateral collateral ligament of the elbow joint: anatomy and kinematics.
Lateral collateral ligament of the elbow joint: anatomy and kinematics.
J Shoulder Elbow Surg. 1996 Mar-Apr ;5(2 Pt 1):103-12.

PubMed
beta-endorphin in plasma and monocytes in juvenile headache.
beta-endorphin in plasma and monocytes in juvenile headache.
Headache. 1996 Feb ;36(2):91-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: