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Mol Microbiol. 1996 Apr;20(2):241-6.

The vacuolating cytotoxin of Helicobacter pylori.

Author information

  • Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2605, USA.

Abstract

Helicobacter pylori, the causative agent of chronic superficial gastritis and duodenal ulcer disease in humans, produces a unique cytotoxin (VacA) that induces cytoplasmic vacuolation in eukaryotic cells. The structural organization and processing of the vacuolating cytotoxin are characteristic of a family of proteins exemplified by Neisseria gonorrhoeae IgA protease. Although only 50% of H. pylori isolates produce detectable cytotoxin activity in vitro, vacA homologues are present in virtually all isolates. Several families of vacA alleles have been identified, and there is a strong correlation between presence of specific vacA genotypes, cytotoxin activity, and peptic ulceration. Experiments in a mouse model of H. pylori-induced gastric damage indicate that the cytotoxin plays an important role in inducing gastric epithelial necrosis.

PMID:
8733223
[PubMed - indexed for MEDLINE]
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