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Clin Exp Rheumatol. 1995 Nov-Dec;13 Suppl 13:S45-9.

HCV and monoclonal gammopathies.

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  • 1Dipartimento di Medicina Interna, Universit√† degli Studi di Modena, Italy.



To determine the prevalence of antibodies against HCV in monoclonal gammopathies with and without cryoglobulinemic activity.


201 patients were divided into two groups: (I) 94 patients with monoclonal gammopathies with cryoglobulinemic activity, and (II) 107 with monoclonal gammopathies without cryoglobulinemic activity. Cryoglobulins were characterized by immunofixation; HCVAb were detected using second-generation ELISA and RIBA methods; in 38 cases the presence of HCV in peripheral blood mononuclear cells was evaluated by PCR.


The HCVAb prevalence, as evaluated by RIBA, in Group I was 69.1% while in Group II it was only 14.9%. Histological and immunohistochemical study of the bone marrow in Group I patients frequently showed signs of nodular B-cell clonal expansion.


Our data confirm the existence of a close correlation between HCV infection and the monoclonal gammopathies with cryoglobulinemic activity. HCV-positive cryoglobulinemic is characterized by self-limiting IgM monoclonal expansion associated with histological aspects of bone marrow lymphoid nodules that do not expand in the course of the disease like classic evolving lymphoproliferative processes.

[PubMed - indexed for MEDLINE]
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