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Curr Opin Oncol. 1996 Mar;8(2):84-8.

Bone marrow transplantation from unrelated donors.

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  • 1University of Texas M.D. Anderson Cancer Center, Section of Bone Marrow Transplantation, Houston 77030, USA.


Unrelated donor bone marrow transplants provide the alternative to allogeneic transplants for patients lacking an HLA-matched related family member donor. Because the donor and recipient have greater immunogenetic disparity than related donor transplants, these transplants are associated with a higher rate of immunologic complications. This disparity has also translated into a lower risk of relapse relative to sibling donor transplants, enabling this treatment to offer a cure to advanced-disease patients.

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