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Dermatology. 1996;192(3):252-4.

Topical treatment with 1% sodium cromoglycate in pyoderma gangrenosum.

Author information

  • 1Department of Dermatology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.

Abstract

BACKGROUND:

Pyoderma gangrenosum is an uncommon skin disease usually treated with systemic drugs, most frequently corticosteroids. Isolated topical treatment is usually considered unsatisfactory.

OBJECTIVE:

To evaluate the effect of topical 1% sodium cromoglycate solution on pyoderma gangrenosum in 5 patients 25-30 years of age.

METHODS:

5 patients, including 2 under systemic steroid treatment, hospitalized in our department from 1992 to 1993 because of pyoderma gangrenosum, were treated with topical 1% sodium cromoglycate solution. Systemic corticosteroids were further added in 2 patients whose initial improvement was inadequate.

RESULTS:

Initial improvement was noted in all 5 patients after 3-7 days of sodium cromoglycate treatment. Complete healing of the ulcers occurred within 5-8 weeks.

CONCLUSIONS:

Topical treatment with sodium cromoglycate can be effective as adjunctive or sole treatment in pyoderma gangrenosum.

PMID:
8726641
[PubMed - indexed for MEDLINE]
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