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Dermatology. 1996;192(3):217-21.

HPV-11- and HPV-16-associated oral verrucous carcinoma.

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  • 1Department of Dermatology, University Hospital, Zurich, Switzerland.

Abstract

BACKGROUND:

Verrucous carcinoma is a slowly growing, well-differentiated neoplasm with a predilection for the oral cavity.

OBJECTIVE:

Data on the association of human papillomavirus (HPV) with oral verrucous carcinoma are very scarce. We searched for the presence of HPV in different stages of the tumour in a patient repeatedly treated by means of surgery, cryotherapy, radiotherapy and chemotherapy over a decade.

METHODS:

HPV DNA was detected in archival tumour tissue by nested PCR. HPV types were identified based on restriction fragment analysis.

RESULTS:

HPV type 11 was found in 1 early-stage and HPV 16 in 2 late-stage biopsy specimens of the tumour.

CONCLUSION:

Our findings provide further evidence for a role of HPV in oral verrucous carcinoma. The case history emphasizes the importance of a joint clinicopathological approach to this tumour.

PMID:
8726634
[PubMed - indexed for MEDLINE]
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