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Immunoglobulin class switching.
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655-0122, USA.
Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity of the heavy-chain class to which a B cell is switched is regulated by cytokines and B-cell activators at the level of transcription of unrearranged heavy chain constant genes. Gene-targeting experiments in mice have proved the essential role of these transcripts in switch recombination. Their possible functions are discussed in the context of a model for the mechanisms of class switching.
PMID: 8725943 [PubMed - indexed for MEDLINE]
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Cited by 33 PubMed Central articles
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CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection.
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[PLoS One. 2009]
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[World J Gastroenterol. 2009]
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ReviewMechanism and regulation of class switch recombination.
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[Annu Rev Immunol. 2008]
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