Immunoglobulin class switching. [Curr Opin Immunol. 1996]

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1: Curr Opin Immunol. 1996 Apr;8(2):199-205. Links

Immunoglobulin class switching.

Stavnezer J.

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655-0122, USA.

Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity of the heavy-chain class to which a B cell is switched is regulated by cytokines and B-cell activators at the level of transcription of unrearranged heavy chain constant genes. Gene-targeting experiments in mice have proved the essential role of these transcripts in switch recombination. Their possible functions are discussed in the context of a model for the mechanisms of class switching.

PMID: 8725943 [PubMed - indexed for MEDLINE]

ReviewThe molecular events in heavy chain class-switching. [Semin Immunol. 1989]
Ku80 is required for immunoglobulin isotype switching. [EMBO J. 1998]
Generation of switch hybrid DNA between Ig heavy chain-mu and downstream switch regions in B lymphocytes. [J Immunol. 1998]
Interallelic class switch recombination contributes significantly to class switching in mouse B cells. [J Immunol. 2005]
ReviewEvolution of isotype switching. [Semin Immunol. 2004]

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Immunoglobulin class switching.

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