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Genetics. 1996 Jun;143(2):713-21.

Destabilization of simple repetitive DNA sequences by transcription in yeast.

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  • 1Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.

Abstract

Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.

PMID:
8725221
[PubMed - indexed for MEDLINE]
PMCID:
PMC1207331
Free PMC Article
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