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Antimicrob Agents Chemother. 1996 May;40(5):1282-4.

Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells.

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  • 1Division of Molecular Virology and Immunology, Georgetown University, Rockville, Maryland, USA.

Abstract

Penciclovir [9-(4-hydroxy-3-hydroxymethylbut-1-yI)guanine], an effective antiherpesvirus agent, was found to be a potent and selective antiviral agent against intracellular hepatitis B virus (HBV) replication (drug concentration at which a 10-fold decrease in HBV DNA from the average level in an untreated culture was observed [EC90], 1.6 microM) and extracellular virion release (EC90, 0.7 microM) by cultured human hepatoblastoma (2.2.15) cells. Acyclovir and three other related 9-alkoxypurines with activity against either herpesviruses or human immunodeficiency virus were uniformly inactive against HBV. The activity of penciclovir is discussed in relation to recent findings related to its mode of action against HBV.

PMID:
8723485
[PubMed - indexed for MEDLINE]
PMCID:
PMC163310
Free PMC Article
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