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Curr Opin Genet Dev. 1996 Apr;6(2):141-5.

Cutting apart V(D)J recombination.

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  • Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA.


The past year has seen major advances in our understanding of the recombination mechanism by which antibody and T cell receptor genes are assembled during lymphoid development. The initial cleavage events can be carried out in vitro by purified RAG1 and RAG/ protein. In addition, a number of genes involved in later steps of the reaction have been cloned, opening the way for an in-depth biochemical analysis of this critical developmental process.

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