The molecular biology of SRY and its role in sex d...[Reprod Fertil Dev. 1995]

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1: Reprod Fertil Dev. 1995;7(4):713-22.Links

The molecular biology of SRY and its role in sex determination in mammals.

Koopman P.

Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia.

SRY is the gene that initiates the genetic cascade leading to testis development in mammals. Since its discovery in 1990 and the direct demonstration of its male-determining role in transgenic mice, attention has turned to understanding the biochemical mode of action of the SRY gene product, and to the identification of other genes in the sex-determining pathway. Recent progress in these efforts is summarized in this review.

PMID: 8711208 [PubMed - indexed for MEDLINE]

Sry and Sox9: mammalian testis-determining genes. [Cell Mol Life Sci. 1999]
Sry and Sox9 expression during canine gonadal sex determination assayed by quantitative reverse transcription-polymerase chain reaction. [Mol Reprod Dev. 2003]
Characterization of ovine SRY transcript and developmental expression of genes involved in sexual differentiation. [Int J Dev Biol. 1996]
The role of Sry in mammalian sex determination. [Ciba Found Symp. 1992]
Temperature-dependent sex determination in the American alligator: AMH precedes SOX9 expression. [Dev Dyn. 1999]
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The molecular biology of SRY and its role in sex determination in mammals.

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