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1: J R Soc Med. 1996 Jan;89(1):47P-8P.Click here to read Links

ANCA associated with Behçet's disease.

Burrows NP, Zhao MH, Norris PG, Lockwood CM.

Department of Dermatology, Addenbrooke's Hospital Cambridge, England.

Behçet's disease is a multisystem disorder affecting primarily mucocutaneous and ocular sites although the gastrointestinal, cardiovascular, central nervous and respiratory systems may also be involved. Hulusi Behçet, a Turkish dermatologist, first described Behçet's disease in 1937 and suggested a possible infectious aetiology. The pathogenesis of this condition still remains unclear although it is likely that infection acts as a trigger in genetically susceptible individuals. We report a patient with unusual cutaneous manifestations of Behçet's disease and antineutrophil cytoplasmic antibodies (ANCA) directed against the cytotoxic protein, bactericidal/permeability-increasing protein (BPI). This is the first report of Behçet's disease associated with this autoantibody.

PMID: 8709085 [PubMed - indexed for MEDLINE]

PMCID: PMC1295643

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