[The effect of the subchronic administration of calcium-channel blockers on CNS excitability]

Eksp Klin Farmakol. 1996 Jan-Feb;59(1):14-6.
[Article in Russian]

Abstract

The effect of a single day administration of nifedipine (10 mg/kg), cinnarizine (25 mg/kg), verapamile (25 mg/kg), fendiline (10 mg/kg), dilthiazem (10 mg/kg), and diazepam (0.5 mg/kg) on the dynamics of changing a convulsive dose of convulsant was studied on a model of intermittent intracutaneous administration of Corazole (10 mg/kg until convulsions) during 5 days. Repeated intermittent Corazole administrations were found to increase the sensitivity of animals with respect to convulsive effect of the drug. All calcium channel blockers and diazepam increased the convulsive dose of Corazole. In accordance with the hypothesis of anxiety disturbances based on nonspecific CNS activation, a possibility of application of calcium channel blockers as potential anxiolytics is considered.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / pharmacology
  • Calcium Channel Blockers / administration & dosage
  • Calcium Channel Blockers / pharmacology*
  • Central Nervous System / drug effects*
  • Convulsants / administration & dosage
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Injections, Subcutaneous
  • Male
  • Pentylenetetrazole / administration & dosage
  • Rats
  • Seizures / chemically induced
  • Time Factors

Substances

  • Anti-Anxiety Agents
  • Calcium Channel Blockers
  • Convulsants
  • Pentylenetetrazole