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Ann N Y Acad Sci. 1996 Jun 8;785:98-107.

BMP 7 is required for nephrogenesis, eye development, and skeletal patterning.

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  • 1Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. gkarsenty@molgen.mda.uth.tmc.edu

Abstract

In summary, the generation of BMP-7-deficient mice has provided additional evidence that this family of growth factors regulate many morphogenetic processes including but not limited to skeletal development. In particular our experiments demonstrate that BMP 7 acts as an early inducer of glomeruli formation, and that it is required for skeletal patterning and lens formation. Our results not only demonstrate that BMP 7 is involved in the differentiation of several organs during development, but also raise the hypothesis that mutations in the Bmp 7 gene itself or in the genetic pathway could be responsible for several human genetic diseases in which glomerulus formation is impaired.

PMID:
8702187
[PubMed - indexed for MEDLINE]
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