Send to:

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 1996 Jun 8;785:98-107.

BMP 7 is required for nephrogenesis, eye development, and skeletal patterning.

Author information

  • 1Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.


In summary, the generation of BMP-7-deficient mice has provided additional evidence that this family of growth factors regulate many morphogenetic processes including but not limited to skeletal development. In particular our experiments demonstrate that BMP 7 acts as an early inducer of glomeruli formation, and that it is required for skeletal patterning and lens formation. Our results not only demonstrate that BMP 7 is involved in the differentiation of several organs during development, but also raise the hypothesis that mutations in the Bmp 7 gene itself or in the genetic pathway could be responsible for several human genetic diseases in which glomerulus formation is impaired.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk