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Nature. 1996 Aug 8;382(6591):511-7.

Cdc25 cell-cycle phosphatase as a target of c-myc.

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  • 1Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724, USA.


The product of the proto-oncogene c-myc, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the cdc25A gene and activates transcription. Like myc, cdc25A, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires cdc25A. These findings indicate that cdc25A is a physiologically relevant transcriptional target of c-myc.

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