A correlation study was conducted to examine the relationship between results from LifeScan's One Touch II blood glucose monitoring system and laboratory analysis of serum glucose values in neonates. A total of 327 blood samples was obtained from newborn infants in a Level III NICU. The comparison of the paired results showed that the r value was .902. The overall results suggest that the LifeScan One Touch II set in the neonatal mode gives results showing good agreement with standard serum glucose values in neonates with serum glucose values < 100 mg/dl (5.6 mmol/liter).