J Neural Transm Gen Sect. 1995;101(1-3):237-42.

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma.

Nomura T, Ohtsuki M, Matsui S, Sumi-Ichinose C, Nomura H, Hagino Y, Iwase K, Ichinose H, Fujita K, Nagatsu T.

Source

Department of Pharmacology, Fujita Health University School of Medicine, Aichi, Japan.

Abstract

Although the existence of three different cDNA forms of human GTP cyclohydrolase I (GCH I) have been reported (Togari et al., 1992), the full-length sequence of any human GCH I cDNA involving poly (A) tail has not yet been documented. In the present study, we first isolated a full-length cDNA clone encoding human GCH I type 1 from human pheochromocytoma cDNA library. The length of the cDNA insert was 2,921 base pairs including poly (A) tail. RNA blot analysis showed a single mRNA species of 4.0 kb in human pheochromocytoma tissue.

PMID:: 8695054; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

EBSCO

Medical

Pheochromocytoma - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I. [Biochem Biophys Res Commun. 1993]
Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I.
Nomura T, Ichinose H, Sumi-Ichinose C, Nomura H, Hagino Y, Fujita K, Nagatsu T. Biochem Biophys Res Commun. 1993 Mar 15; 191(2):523-7.
GTP cyclohydrolase I from Tetrahymena pyriformis: cloning of cDNA and expression. [Comp Biochem Physiol B Biochem...]
GTP cyclohydrolase I from Tetrahymena pyriformis: cloning of cDNA and expression.
Tazawa M, Ohtsuki M, Sumi-Ichinose C, Shiraishi H, Kuroda R, Hagino Y, Nakashima S, Nozawa Y, Ichinose H, Nagatsu T, et al. Comp Biochem Physiol B Biochem Mol Biol. 2000 Sep; 127(1):65-73.
Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway. [J Biol Chem. 1991]
Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway.
Hatakeyama K, Inoue Y, Harada T, Kagamiyama H. J Biol Chem. 1991 Jan 15; 266(2):765-9.
Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene. [Biochem Biophys Res Commun. 1987]
Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.
Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T. Biochem Biophys Res Commun. 1987 Aug 14; 146(3):971-5.
Multiple mRNA forms of human GTP cyclohydrolase I. [Biochem Biophys Res Commun. 1992]
Multiple mRNA forms of human GTP cyclohydrolase I.
Togari A, Ichinose H, Matsumoto S, Fujita K, Nagatsu T. Biochem Biophys Res Commun. 1992 Aug 31; 187(1):359-65.

See reviews... See all...

Cited by 3 PubMed Central articles

Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease. [Hum Gene Ther. 2004]
Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease.
Sun M, Kong L, Wang X, Holmes C, Gao Q, Zhang GR, Pfeilschifter J, Goldstein DS, Geller AI. Hum Gene Ther. 2004 Dec; 15(12):1177-96.
GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing. [Biochem J. 2001]
GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing.
Golderer G, Werner ER, Heufler C, Strohmaier W, Gröbner P, Werner-Felmayer G. Biochem J. 2001 Apr 15; 355(Pt 2):499-507.
Review Tetrahydrobiopterin biosynthesis, regeneration and functions. [Biochem J. 2000]
Review Tetrahydrobiopterin biosynthesis, regeneration and functions.
Thöny B, Auerbach G, Blau N. Biochem J. 2000 Apr 1; 347 Pt 1:1-16.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from...
Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma.
J Neural Transm Gen Sect. 1995 ;101(1-3):237-42.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Isolation of a full-length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information